Enzymes catalysing conjugations of glutathione with αβ-unsaturated carbonyl compounds
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چکیده
منابع مشابه
Carbonyl Compounds Enols and Enolate Ons. Unsaturated and Polycarbonyl Compounds
ome of the most useful reactions of carbonyl compounds involve carbonhydrogen bonds adjacent to the carbonyl group. Such reactions, which can be regarded as the backbone of much synthetic organic chemistry, usually result in the replacement of the hydrogen by some other atom or group, as in the I I I I sequence H-C-C=O -+ X-C-C=O. The important examples we I I will consider in this chapter are ...
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Booth, Boyland & Sims (1961) described and partially purified an enzyme from the soluble supernatant of rat liver which catalyses conjugations of glutathione with aromatic compounds to form thio ethers as a first stage in mercapturic acid biosynthesis, and an apparently similar enzyme has been shown to be involved in processes leading to the biliary excretion of sulphobromophthalein (phenoltetr...
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A cDNA clone, lambda GTRA8, encoding rat glutathione transferase subunit 8 has been isolated from a lambda gt10 rat hepatoma cDNA library. The previously known amino acid sequence of the enzyme was used to design primers for a polymerase chain reaction that yielded a 0.3 kb DNA fragment from the hepatoma library. The 0.3 kb fragment was used as a probe for screening and a 0.9 kb cDNA clone cont...
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Two cobalt-carbonyl oxo processes were developed to prepare useful products in high yield from fatty derivatives. In one process, hydroformylation in the presence of MeOH at 120 C gives dimethyl acetal esters from either methyl oleate or oleic acid. In the other, a two-step process, hydroformylation (120 C) followed by hydrogenation (180 C) gives better yields of hydroxY methyl esters from both...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1968
ISSN: 0306-3283
DOI: 10.1042/bj1090651